他汀类药物对心血管的保护作用

Beneficial Cardiovascular Pleiotropic Effects of Statins

他汀类药物(statins)被研制出来的最初目的是降低血脂,但是现在发现它不仅具有降低血脂的作用,还具有很多其他的作用取包括改善内皮细胞功能的紊乱,提高内皮源性一氧化氮合成酶(eNOS)的生物活性,抑制血管平滑肌细胞的增生,抗氧化作用,抗炎作用,降低血压,逆转心血管系统的重构。充分的理解 statins 的多效性作用及机制有利于它更好的在临床中被用于心血管系统的预防和治疗。

pleiotropic effect of a drug are actions other than this for which the agents were developed.This effect maybe desired or undesired,and maybe unrelated to their primary mechanism.Statins were designed as drug of reducing cholesterol,but now pleiotropic effect are found including improvement of endothelial dysfunction,increasing eNOS bioavailability,antioxide effect,antiinflammatory properties,reduction of hypertension.Understanding this effects is important to treatment and prevention of cardiovascular disease.