期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

色素上皮源性因子——种新的神经营养和保护因子 被引量：3

Pigment Epithelium-Derived Factor(PEDF)-a New Neurotrophic and Protected Factor
下载PDF
导出
摘要 PEDF 是最近发现的一种神经营养因子,在许多组织均由表达。它具有强大的营养和保护神经作用。已有研究显示其作用机制主要涉及 N-端结构域,改变细胞内钙离子,影响其它因子和胶质细胞而发挥作用等等。它对于神经疾病的治疗可能具有很大的潜力。 Pigment Epithelium-Derived Factor(PEDF)has been found recently as a new neurotrophic factor.It expresses in many tissues.It has powerful neurotrophic and neuroprotective activity.Previous studies appear that the mechanism for the action of PEDF involves the N-terminal region,alteration of intracellular free calcium,and its influence on other factors,or gila.PEDF might become a valuable therapeutic agent in neurologic diseases.
作者 李锐 盛文利
机构地区 中山大学第一附属医院神经科
出处 《中山大学研究生学刊（自然科学与医学版）》 2004年第4期21-27,共7页 Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
关键词 色素上皮源性因子 神经营养因子 治疗 保护因子 改变 神经疾病 细胞内钙离子 结构域 PEDF 胶质细胞 Pigment Epithelium-derived Factor(PEDF) Neurotrophy Neuroprotection
分类号 R77 [医药卫生—眼科] R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Tombran-Tink,J,Johnson,L,V.Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells[].InvestOphthalmolVisSci.1989
  • 2Tombran-Tink,J,et al.Organization,evdutionary conservation,expression and unusual Alu density of the human gene for pigment epithelium-derived factor,a unique neurotrophic serpin[].Molecular Vision.1996
  • 3Steel,F.,R Chader,G.J.Johnson,Tombran-Tink,J.Pigment epithelium-derived factor:neurotrophic activity and identification as a member of the serine protease inhibitor gene family[].Proceedings of the National Academy of Sciences of the United States of America.1993
  • 4Elena Alberdi,Maria Soledad Aymerich,and S Patricia Becerra.Binding of Pigment Epithelium- derived Factor(PEDF) to Retinoblastoma Cells and Cerebellar Granule Neurons[].Journal of Biological Chemistry.1999
  • 5Bilak,M.M.et al.Identification of the neuroprotective molecular region of pigment epitheliumderived factor and its binding sites on motor neurons[].Journal of Cognitive Neuroscience.2002
  • 6Alberdi EM,Weldon JE,Becerra SP.Glycosaminoglycans in human retinoblastoma cells:heparan sulfate,a modulator of the pigment epithelium-derived factor-receptor interactions[].BMC Biochemistry.2003
  • 7Taniwaki,T.et al.Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity[].Journal of Neurochemistry.1997
  • 8Bilak,M.M.et al.Pigment epithelium-derived factor(PEDF)protects motor neurons from chronic glutamate-mediated neurodegeneration[].JNeuropatholExpNeurol.1999
  • 9Susan E.et al.Pigment epithelium-derived factor(PEDF)in neuroblastoma:a multifunctional mediator of Schwann cell antitumor activity[].Journal of Cell Science.2001
  • 10Palmieri,D,Watson,J.,& Rinehart,C.Age-related expression of PEDF/EPC-1 in human endometrial stromal fibroblasts:implications for interactive senescence[].Experimental Cell Research.1999

同被引文献28

  • 1秦柏,管怀进,张俊芳,沈爱国.视神经夹伤合并晶状体损伤大鼠视网膜中神经元型一氧化氮合酶的表达[J].眼科新进展,2013,33(12):1128-1131. 被引量：2
  • 2李锐,盛文利.色素上皮源性因子神经营养和保护因子[J].国外医学（神经病学．神经外科学分册）,2005,32(3):289-292. 被引量：5
  • 3胡鹭萍,徐国兴.色素上皮衍生因子在视网膜疾病中的应用研究进展[J].海峡科学,2007(3):73-77. 被引量：1
  • 4Shen X,Xu G. Role of IL-1 beta on the glutamine synthetase in retinal Muller cells under high glucose conditions[J]. Curt Eye Res, 2009,34(3) :727-736.
  • 5Ishikawa A, Ishiguro S, Tamai M,et al. M changes in GABA metabolism in streptozotocin-induced diabetic rat retinas [J]. Curt Eye Res, 1996,15(1) :63-71.
  • 6Ambati J,Chalam K V,Chawla D K, et al. Elevated gamma aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative dia betic retinopathy[J]. Arch Ophthalmol, 1997, 115 (9): 1161-1166.
  • 7Hutchinson P J,O Connell M T, Ai-Rawi P G, et al. Increases in GABA concentrations during cerebral ischaemia: a microdi- alysis study of extracellular amino acids[J] J Neurol Neuro- surg Psychiatry, 2002,72 (1) : 99-105.
  • 8Araki T, Taniwaki T, Beeerra S P, et al. Pigment epithelium- derived factor(PEDF) differentially protects immature butnot mature cerebellar granule cells against apoptotic cell death [J]. Neurosci Res, 1998,53(1) : 7215-7219.
  • 9CayouetteM,Smith S B, Becerra S P,et al. Pigment epitheli- um derived factor delays the death of photoreeeptors in mouse models ofinherited retinal degenerations[J]. NeurobiolDis, 1999,6(6):523-532.
  • 10Boehm B O, Lang G, Feldmann B, et al. Proliferative diabetic retinopathy is associated with a lowlevel of the natural ocular anti-angiogenic agent pigment epithelium-derlved factor (PEDF) in aqueous humor[J]. Horm Mebab Res, 2003,35 (6):328 336.

引证文献3

二级引证文献3

中山大学研究生学刊（自然科学与医学版）
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部