疟疾与ABO血型关系的探讨

STUDIES ON THE RELATIONSHIP BETWEEN SUSCEPTIBILITY to MALARIA Infection AND ABO BLOOD GROUP

西双版纳勐捧乡经镜检确诊的疟疾患者计102例,当地正常人1011名同时进行ABO血型检测;A,B,O和AB血型者依次分别为26、29、40和7例及162、345、450和54名。通过对两组人群的ABO血型基因频率及各血型人群罹患疟疾相对危险率的计算,发现A血型人群较易感染疟原虫,其相对危险率较其他血型者高1.79倍(X^2=5.9146,P<0.05)。

ABO blood grouping was performed in 102 microscopically confirmed malaria patients from Mengpeng, Xishuangbanna. Twenty-six, 29, 40 and 7 cases were identified as A, B,O and AB phenotypes respectively. Meanwhile, 1011 normal individuals were examined as controls to obtain the baseline of the distribution of phenotypes. Studies comparing the distribution of genotype frequencies and relative crisis rates in ABO blood group among malaria patients with the controls by Chi-square test showed that phenotype A appeared more frequently and significantly in malaria cases. The susceptibility was 1.79 times higher than that of those with non A phenotypes as measured by relative crisis rate (x2 = 5.9146, p<0.05).