糖尿病与高血压病患者血管内皮功能的变化特点

The changes of endothelial function of blood vessels in diabetes mellitus and essential hypertension

目的 利用多普勒超声检测糖尿病与高血压病的血管内皮功能 ,评价其变化特点。方法 运用多普勒超声对2 5例糖尿病 (DM )及 2 5例高血压病 (EH)患者和 2 0例正常人肱动脉充气加压及舌下含服硝酸甘油前后血管直径的变化进行观察。结果 DM和EH组充血状态下内径扩张程度较正常对照组明显减低。含服硝酸甘油后DM组内径扩张程度较正常对照组明显减低 ,EH组无显著性改变。结论 DM患者存在内皮依赖性舒张功能及非依赖性舒张功能障碍 ,EH患者内皮依赖性舒张功能障碍 。

Objective To study the endothelium-dependent d il atative function (EDDF) in the patients with diabetes mellitus (DM) and essentia l hypertension (EH). Methods A total of 25 DM patients and 25 EH were chosen as the experimental group and 20 matched normals were chosen a s the control group. EDDF was assessed with B-mode ultrasonography for the chan ges in the diameter of the brachial artery during reactive hyperemia and after t aking in nitroglycerin. Results The changes of brachial art ery diameter during reactive hyperemia were slighter in DM and EH patients. The changes of branchial artery diameter after sublingual glyceryl trinitrate were s lighter in DM patients. Conclusion Endothelial dysfunction exist in the patients with DM; and endothelium-dependent vasodilatative dysfunc tion exist in the patients with EH.