按摩并吗丁啉对糖尿病性胃轻瘫患者胃动素及胃排空时间的影响

Effects of massotherapy in conjunction with domperidone on motilin and gastric emptying time of patients with diabetic gastroparesis

目的 研究按摩并吗丁啉对糖尿病性胃轻瘫 (DGP)患者胃动素、胃排空时间的影响。方法 将 10 0例DGP患者随机分为治疗组与对照组 ,每组各 5 0例。对照组予吗丁啉片 ,治疗组予按摩配合吗丁啉治疗 ,观察 6周。结果 治疗组和对照组总有效率分别为 92 %和 78% (P <0 .0 5 ) ,两组胃动素、胃排空时间均降低 (P <0 .0 5 ) ,但治疗组优于对照组 (P <0 .0 5 )。结论 按摩并吗丁啉对降低DGP患者的血浆胃动素、胃排空时间具有积极作用。

Objective To investigate the therapeutic effect of massotherapy in conjuction with domperidone on motilin and gastric emptying time of patients with diabetic gastroparesis(DGP). Methods One hundred cases of DGP were randomly and equally divided into a control group ( n =50) and a therapy group ( n =50). The control group was treated with domperidone. The therapy group was treated with massotherapy in addition to domperidone. Both groups were observed for 6 weeks. Results The total effective rate in the therapy group and control group was 92%and 78%, respectively ( P <0.05). Motilin and the gastric emptying time were decreased obviously in both groups ( P <0.05), with that they were significantly lower in the therapy group as compared with those of the control group ( P <0.05). Conclusion The method of massotherapy in conjunction with domperidone has positive effects on DGP patients with regard to its effect in reducing serum motilin concentration and gastric emptying time.