肝癌病人的凝血因子X和蛋白C的羧化异常

r-CARBOXYLATION DEFICIENCY OF CLOT FACTOR X AND PROTEIN C IN HEPATOCELLULAR CARCINOMA

作者建立了异常凝血因子Ⅹ和异常蛋白C的蛇毒激活显色底物检测法,并在此基础上,对原发性肝细胞肝癌(HCC)病人血浆中凝血因子Ⅹ和蛋白C的羧化异常进行了研究。发现在12例HCC患者中,有10例病人血浆中羧化不完全的异常凝血因子Ⅹ含量高于3％;有9例羧化不完全的异常蛋白C含量高于10％。据此推断,羧化异常不仅发生于凝血酶原,同时也发生于其他凝血因子如因子Ⅹ和抑制凝血的蛋白C结构中,羧化异常具有普遍性。据此,血浆异常因子Ⅹ及异常蛋白C均有可能成为肝细胞肝癌的诊断标志。

Abnormal clot factor X and abnormal protein 0 were assayed by snake venom activators and chromogenic substrates for the study of glutamyl carboxylation deficiency in hepatocellular carcinoma. In 12 patients with HCC, plasma concentration of undercarboxylated clot factor X was over 3% in 10 cases, while that of undercarboxylated protein 0 was over 10% in 9 cases. It was concluded that the r-carbosylation deficiency in HCC was involved not only in prothrombin, but also in other clot factors, such as factor X, and in anti-clot factors, such as protein 0. This suggests that these abnormal factors could also be used as possible diagnostic markers of hepatocellular carcinoma.