鳞癌相关抗原在食管鳞癌中的临床检测价值

CLINICAL SIGNIFICANCE OF SERUM SCC AG IN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA

用免疫放射量度分析法测定52例食管鳞癌病人血清中的鳞癌相关抗原(SCC Ag)浓度,发现SCC Ag浓度与病期密切相关,总阳性率(>1.5ng/ml)为63.5％,Ⅰ～Ⅳ期阳性率分别为0、25、73.1和85.7％。SCC Ag在根治性切除术后可在72h内降至正常,若肿瘤未彻底切除则不能显示同样改变。SCC Ag在肿瘤复发或转移时重新显著增高,并先于临床表现。研究结果表明,SCC Ag能反映肿瘤的情况,有助于食管鳞癌的辅助诊断、预测预后、监测手术疗效及病情变化,及早发现复发或转移。

The serum level of squamouS cell carcinoma associated antigen (SOU Ag)wag studied by immunoradiometric assay (IJRMA) in 52 patients with squamous cell carcinoma of esophagus. 63.5% of patients was found to be positive (>1.5ng/ ml),SCC Ag level correlated well with extent and severity of the disease; 0% in stage Ⅰ, 25% in stage Ⅱ, 73.1% in stage Ⅲ and 86.7% in stage Ⅳ. SCC Ag level declined rapidly to normal within 72 hours after curative surgery, but it did not be show Such change if complete tumor excision oould not be performed. SCC Ag level increased again markedly during recurrence or matastases, and preceding clinical evidence of relapse by 2-6 months in some cases, .Results of this study indicated that serum SCC Ag level may reflect the extent of disease, it could be used as an adjunct in assisting diagnosis, predicting prognosis, detecting recurrence or metastases and monitoring surgical effect and disease status for esophageal squamous cell carcinomas.