甲状腺功能亢进和减低实验大鼠心钠素和肾素-血管紧张素-醛固酮系统的观察

ATRIAL NATRIURETIC POLYPEPTIDE IN PLASMA,ATRIA AND PLASMA RENINAGIOTENSION-ALDOSTERONE SYSTEM IN EXPERIMENTAL HYPERTHYROID AND HYPOTHYROID RATS

本文检测甲亢甲减实验大鼠血浆、心房心钠素(ANP),血浆肾素活性、血管紧张素Ⅱ和醛固酮含量,并与正常大鼠进行比较。发现(1)甲亢大鼠血浆 ANP 显著升高,心房 ANP 显著低下,甲减大鼠两者呈相反变化:(2)血浆 ANP 和血清 T_4呈正相关,(3)甲亢和甲减大鼠肾素活性和血管紧张素Ⅱ分别呈明显升高和降低;醛固酮水平则无明显变化。上述结果提示甲亢时心房释放 ANP 增加,甲减时释放减少;异常甲状腺功能状态下,血浆 ANP 与肾素-血管紧张素-醛固酮系统相互作用对维持体液平衡有一定意义。

The concentrations of plasma and atria atrial natriuretic peptide(ANP),plasmarenin activity(PRA),agiotension_(Ⅱ)(A_(Ⅱ)),and,aldosterone(ALD)in experimental hy-perthyroid and hypothyroid rats were measured,and compared with euthyroid rats.Plasma ANP was higher(P<0.01)in hyperthyroid rats and lower(P<0.05)in hypo-thyroid rats than that in euthyroid rats.ANP concentration in the atria was lower(P<0.01)in hyperthyroid rats and higher(P<0.05)in hypothyroid rats than thatin control group.An positive correlation was found between the Plasma ANP and se-rum T_4 in different thyroid states(n=28,r=0.839,P<0.01).Plasma PRA and A_(II)was higher(P<0.01 and P<0.05)in hyperthyroid and lower(P<0.01 and P<0.05)in hypothyroid rats than that in euthyroid rats.There were no significant difference(P>0.05)in plasma ALD levels among hyper-,hypo and euthyroid rats.The resultssuggest an increased release of ANP from the atria in hyperthyroidism and a decreasedrelease of ANP from the atria in hyperthyroidism and the effects of ANP and renin-agiotension-aldosterone system on maintaining the equilibrium of water and electroly-tes may be an important in thyroid dysfunction.