子宫内膜异位症和流产及不孕患者血清12种自身抗体的分析

ANALYSIS OF 12 SERUM AUTOANTIBODIES IN PATIENTS WITH ENDONIETRIOSIS STERILITY AND ABORTION

检测69例健康孕妇和225例子宫内膜异位症(EMT)、流产和不孕患者血清中 EMAb、ANA、A-dsDNA、A-Sm、A-RNP、A-TG、A-TM、RF、AphA、InAb、CaMAb、ANCA 等12种自身抗体,健康孕妇 EMAb 阳性率为1.4%,其他抗体的总阳性率为4.3%;EMT(n=66)、流产(n=87)和不孕(n=72)组患者 EMAb 阳性率分别为72.7%、37.9%和38.9%,其余11种自身抗体的总阳性率分别为51.5%、24.1%和19.4%,均显著高于健康孕妇(P<0.01)。结果提示:EMT 患者体内存在高水平自身免疫反应,某些自身抗体的增加,可能影响正常生育。

Serum samples from 69 healthy pregnant women and from 225 patients with endo- metriosis(EMT),sterility and abortion were tested for 12 autoantibodies to endometrium, nuclear,double-stranded DNA.Smith,ribonucleoproteins,thynoglobulin,thyromicrosomal, rheumatic factor,phospholipid,insulin,calmodulin neutrophil cytoplasmic antigens.The positives rate of antiendometrial antibodies was 1.4% and the other 11 autoantibodies in healthy pregnant women was 4.3%.In patients with EMT (n=66),abortion (n=87) and sterility(n=72),the antiendometrial antibodies were positive in 72.7%,37.9% and 19.4%,respectively and the positive rates of the other 11 autoantibodies were 51.5%,24.1%,and 19.4%,respectively.The difference was statistically significant (p 0.01).This finding indicates a high level of autoreactivity in women with endome- triosis and the normal fertility may be affected by increase of some autoantibodies.