系统性红斑狼疮患者外周血单个核细胞中C-myc和ras癌蛋白的表达及NK亚群的状况

EXPRESSION OF C-MYC,KI-RAS AND HA-RAS ONCOPROTEINS AND SUBSETS OF NATURAL KILLER CELLS IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

作者检测了系统性红斑狼疮(SLE)患者外周血单个核细胞(PBMC)中 C-myc.Ki-ras 和Ha-ras 三种癌蛋白的表达和自然杀伤细胞(NK)亚群状况。结果显示,SLE 患者血液淋巴细胞和单核细胞中上述三种癌蛋白的阳性率均显著高亍健康对照组(P<0.001);而 SLE 组 NK 总数和CD16^+.CD16^+.57^+亚群细胞数则显著低于对照组(P<0.001)。作者结合文献讨论了 SLE 患者PBMC 中癌基因激活的可能机制和重要意义,以及与 NK 细胞和其亚群改变之间的相互关系。

Expression of C-myc,Ki-ras and Ha-ras oncoproteins and subsets of natural killer (NK)cells in the peripheral blood mononuclear cells(PBMC)from patients with systemic lupus erythematosus(SLE)were studied.In patients with SLE,the positive percentages of all three kinds of oncoproteins in both lymphocytes and monocytes were significantly increased compared with the healthy controls.The number of NK cells and CDI6^+,CD16^+,57^+subsets cells in SLE patients was markedly lower than that in the healthy controls.The possible mechanism and clinical significance on the expression of oncoproteins in PBMC from SLE patients,and the interrelation between oncogenes expression and the decrease of NK cells were discussed.