界面活性剂对阿斯匹林片剂溶出速度的影响及其机制的研究

EFFECTS OF SURFACTANTS ON THE DISSOLUTION RATE OF ASPIRIN FROM TABLETS IN WATER

本文考察了三种不同类型界面活性剂月桂醇硫酸钠(SDS),吐温-80(TEN)及十六烷基三甲基溴化铵(CAB),对难溶性固体药物阿斯匹林(ASPN)片剂溶出速度的影响,并进一步探讨了其作用机制。实验表明界面活性剂CAB和TEN对ASPN具有改善润湿及反絮凝作用,可明显增加水中ASPN的溶解及其片剂的溶出,胶团增溶作用经测定是很有限的,不能说明ASPN水中溶解的显著增加。界面活性剂SDS对ASPN的润湿、增溶及其片剂的溶出均没有明显作用。认为与界面活性剂及药物分子的结构和性质密切相关。

In this paper, the effect of surfactants, Sodium dodecyl sulphate (SDS), Tween-80 (TEN) and Cetyltrimethylammonium bromide (CAB), on the dissolution rate of Aspirin (ASPN) tablets is reported and the action mechanism of the surfactants is illustrated, Experiments showed that CAB and TEN could effectively improve the wetting of ASPN powder and have important action of deflocculation in ASPN suspension, which resulted in the increase of the dissolution rate of ASPN tablets. But the solubilization capacity of the surfactant micelles was much too small to account for the remarkable increase in the disslution. Meanwhile it was also found that SDS had no part in improving the dissolution. Therefore, it seems that the above results are related only to the structural properties of surfactants and the drug moleculars.