摘要
采用7日龄大鼠右侧颈总动脉结扎合并高温低氧环境制作的脑低氧缺血(hypoxia-ischemia)模型,观察神经生长因子(NGF)对新生动物纹状体胆碱能递质改变的影响。新生鼠结扎合并低氧后,脑室内一次注射NGF,可防止24h后纹状体乙酰胆碱(ACh)含量及乙酰胆碱酯酶(AChE)组织化学图像定量的改变,上述结果提示,新生鼠脑低氧缺血早期应用NGF对因低氧缺血所引起的新生鼠脑纹体胆碱能系统的变化有保护作用。
Cerebral hypoxia--ischemia was produced in 7 day old rats by right common carotidartery occluion combined with systemic hypoxia. In the hypoxic-ischemic group ani-mals, striatal ACh contents on both sides were reduced to a significant extent in com-mensurate to AChE histochemical image analysis. All these changes could be restored tonormal control by a protection dose (50 μg) of NGF intraventricularly injected.
出处
《生理学报》
CAS
CSCD
北大核心
1993年第4期325-329,共5页
Acta Physiologica Sinica
基金
国家自然科学基金(No.3880433)
广东省科学基金(No.90014)
关键词
纹状体
乙酰胆碱
脑缺血
低氧
cerebral hypoxia-ischemia
striatum
acetylcholine
acetylcholinesterase
nerve growth factor
