结节性甲状腺肿及其非典型结节与甲状腺癌细胞核DNA定量研究

A PRIMARy STUDy ON NODULAR GOITER,ATYPICAL NODES AND DNA CONTENT OF THYROID CANCER CELLS

作者对结节性甲状腺肿及其非典型结节与甲状腺癌细胞核直径、面积及 DNA 含量检测,发现核直径与面积的(?)和 S 为甲状腺癌组>非典型结节组>对照组(P<0.01);随着细胞增生异型程度的加重,核直径、面积及离散程度随之增加、DNA 含量也显著增加,显示Ⅲ级 DNA 含量细胞出现频率越高恶性的可能性就越大;同时发现各组细胞核不同 DNA 含量的核直径、面积均明显增加,与对照组相比差异生非常显著(P<0.01)。

Nodular goiter,atypical nodes and the DNA content,diameter and area of thyroid cancer cell nulei were studied.Our findings are:the and S of the diameter and area of the thyroid cancer group>the atypical node group>the contrast group (P<0.01);the diameter area and disp- ersion degree increase along with the abnormality of cell multiplication, and there is a marked increase in DNA content;the higher frequency of third—grade DNA—content cells,the more possibility of the benign case;at the same time,the caryon DNA content of the above—mention ed groups is defferent in their caryon diameter and area.(P<0.01).This study is done with Feulgen DNA staining which is an easy and simple way for semi—quantitative detecton,and it is of some value in diffe- rentiating benign lesion from malignant lesion and in clinical prognosis for treating carcinoma.