摘要
本文对55例甲状腺乳头状癌间质进行定量观察,研究间质反应特点与生物学意义的关系,作者认为:①不论恶性度高低,瘤边及癌巢间浸润的淋巴细胞量普遍多,提示其在抗肿瘤反应中起主导作用,且以细胞免疫为主;②间质内网状纤维反应在抗肿瘤过程中与宿主的免疫反应起着相互协同、相互影响的作用;③癌巢间及肿瘤边胶原纤维分两型,均是宿主对抗肿瘤的防御反应,两型反应越显著、量越多,则揭示宿主的抗肿瘤反应能力越强;④癌实质中出现钙化小球不但能提示癌细胞生长缓慢以及局部有变性坏死,亦可视作为宿主抗肿瘤防御反应能力强的形态学标志,尤以若同时伴有大量淋巴细胞浸润时可视作为免疫活性细胞攻击杀伤癌细胞能力强的形态学证据。
A quantitative research has been carried out on thyroid papillary carcinoma of 55 cases,stdying the characteristics ofmesenchymal reaction and its biological relationship.The athors found.1)NO matter how malignant it might be,there must be a large volume of infitrative lymphocytes between the tumormargin and the cancer nest,it suggests lymphocytes play a leading role in resistance to tumor with cytoimmunity as the mainforce.2)The reaction of reticular fibers correlate inter reaction with host immunity in the course of resistance to tumor.3)The collagenous fibers between the cancer nests and the tumor margins can be divided into two types,either type man-ifests the host defensive reaction to tumor.The more marked reaction,the larger volume means the stronger reaction on thepart of the host to tumor.4)The presentation of calcified glomeruli in the cancer parenchyma can not only predicts the sluggish growth in cancer,but also be the morphological symbol of the host's defensive reaction to tumor,i.e.if there's a large quantity of lymphocyticinfiltration,it might be a proof of the forceful killing attack of immune competent ceils against tumor.
基金
新疆维吾尔自治区卫生厅青年科学基金
