应用hMG-hCG及人工授精治疗不育症

Induction of Ovulation with hMG-hCG and Artificial Insemination on Treatment of Female Infertility in the Clinic

门诊应用hMG-hCG治疗下丘脑-垂体功能障碍引起的闭经、月经稀发和月经正常周期小卵泡不育患者28例38个周期,以B 超、宫颈评分作为主要监测手段,结合采用不同人工授精方法。结果28例38个周期均有排卵,20例妊娠,总妊娠率为71.43%,2例双胎,2例流产,流产率为10%(2/20)。3个治疗周期出现中度OHSS,发生率7.8%(3/38)。

28 Cases of infertile patients of amenorrhea,oligohypomenorrhea and small ovarian follicle dueto hypothalamic-pituitary disfunction treated with human menopansal gonadotropin(hMG)werestudied.Follicular development and ovulatory events were monitored by cervical score and serialultrasonography.The different methods of artificial insemination were used for the infertile couples.Among 9 couples who had good CS and azoospermia were treated with intracervical insemination(ICI)of unwashed donors semen.The intrauterine insemination(IUI)were used for 8 infertile couples due tohostile cervical mucus or abnormal husban's semen with washed husband's spermatoyoa.11 infertilecouples who had good cervical score and normal husband semen had natural intercourse.Of 38treatment cyclas,inductive ovulation occnrred in all cycles.20 infertile patients became pregmant(7cases of ICI,7 cases of IUI,6 cases of natural interconrse).Total pregnancy rate were 71.43%.18of them had full term deliveries(including 16 Singles,2 twins),and 2 abortions.Three moderate casesof ovarian hyperstimulation syndrome(OHSS)occurred in the ovulatory cycles.Rate was 7.8%(3/38).Prevention of OHSS and improvement of the effectiveness of the treatment were dicussed.Thewriter suggested that the application of hMG-hCG-ICI or hMG-hCG-IUI in the clinic were safe,effective and inexpensive for the treatment of infertility.