维拉帕米、阿托品、哇巴因、乙酰唑胺对兔输卵管液分泌的影响

Effects of Verapamil(Ver),Atropine(Atr),Ouabain(Oua),Acetazolamide(Ace)on Secretion of Oviduct Fluid in Rabbit

本文在急性实验条件下采取输卵管液,用ICP 直读光谱仪测定元素浓度。结果表明:钙拮抗剂:维拉帕米(Ver),抗胆碱药:阿托品(Atr),碳酸酐酶抑制剂:乙酰唑胺(Ace)可使动情兔输卵管液分泌量减少。Ver 和Atr 可使输卵管液中钙的浓度下降,而对输卵管液中铜、锌、铁、镁、钾、钠、磷等七种元素的浓度没有影响。Ace 可使输卵管液中铜和钾的浓度增加。而对钙、锌、铁、镁、钠、磷等六种元素的浓度没有影响。Na-K-ATP 酶阻断剂:哇巴因(Oua)对输卵管液的分泌量和元素的浓度均无显著影响。

Experiments were performed on 30 rabbits under urethane anesthesia.The content of elements(Cu^(2+),Fe^(2+),Zn^(2+),Ca^(2+),Mg^(2+),K^+,Na^+,P)were measured by ICP.The test objects were dividedinto control,verapamil,airopine,ouabain and acetazolamide groups.The results showed:(1)The Ver,Atr,Ace decreased content of oviduct fluid output significantly after treatment.(2)Both Ver and Atrdecreased level of Ca^(2+)in the oviduct fluid significantly after treatment.(3)The Ace increased levelsof Cu^(2+)and K^+ in the oviduct fluid significantly after treatment.(4)The Oua did not effectsecretion of oviduct fluid.It was suggested that Ver,Atr and Ace exert a certain inhibitory influence on the secretion ofoviduct fluid in estrous rabbit.