摘要
450例闭经49天以内的早孕妇女,随机分成两组。试验组给国产米非司酮25mg,每日口服2次,连服3天(总剂量150mg),第4天经阴道给卡前列素栓1mg,共300例。对照组给予同样剂量的国产米非司酮后经阴道给PG 05 1mg,共150例。结果:前者的完全流产率为89%,后者为94%,两组抗早孕效果无统计学差异(P>0.05)。然而前者作用缓慢,腹痛、腹泻、呕吐等副反应较后者明显减少、减轻(P<0.001)。而后者作用快,孕囊排出时间短,6h 内排出的比例高(P<0.05)。
450 women of early pregnancy(amenorrhea≤49 days)were ramdomly treated with Mifepristone 25mg tiwce daily for 3 days,combined with a suppository of lmg Carboprost(300 cases),or a suppository of lmg PG05(150 cases)on the 4th day.Results showed thatcomplete abortion rates were 89.0% and 94.0%,respectively.There was no statisticalsignificance for them(P>0.05).However,side effects such as abdominal pain,diarrhea,andvomiting,occurred significantly the PG05 suppository group than in Carboprost suppository group(p<0.001).It was concluded that the combination of Mffepristone with a single suppository ofCarboprost or PG 05 was effective in early pregnancy iermination.Side effects in Carboprostsuppository group were milder than those in PG05 group,but the effect in PG05 suppositorygroup was more rapid than in Carboprost suppository group.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1993年第6期436-441,共6页
Reproduction and Contraception
关键词
卡前列素栓
米非司酮
抗早孕
Carboprost suppository,PG05,Mifepristone,Induced abortion