米非司酮对早孕妇女血凝-纤溶系统的影响

The Effects of Mifepristone on Coagulation and Fibrinolytic Systems in Early Pregnant Women

本文报道米非司酮四种抗早孕用药方案对孕妇血凝-纤溶系统九种参数(PT、KPTT、VⅡ:C、VⅢ:C、VWF、ATⅢ:C、ATⅢ:Ag 以及α2-MG、Pg 抗原水平)的影响。应用SAS 统计软件包对实验数据进行统计分析。结果显示:四组间用药前每一种参数值均无显著差异,四组间相同时间PT、KPTT、ATⅢ:Ag 和α2-MG 水平无显著差异。组Ⅱ(50mg×6)作用较明显,VⅡ:C、VⅢ:C 分别明显低于组Ⅰ(50mg)和组Ⅲ(200mg)。此外,组Ⅱ和组Ⅳ(600mg)的VWF 明显低于其他两组。结果提示米非司酮抗早孕时低剂量多次用药(50mg×6)对血凝-纤溶的影响比大剂量(600mg)一次用药明显,其综合效应是具有抑制凝血活性的倾向。但结合临床,这种作用并不是导致出血过多或时间过长的主要原因。

The paper reported the effects of four different regimens of RU486 on clotting and fibrinolytic systems in pregnant women.Nine parameters(PT、KPTT、Ⅶ:C、Ⅷ:C、VWF、ATⅢ:C、 AT-Ⅲ:Ag、α 2-macroglobulin and plasminogen antigen levels)were determined.All the datawere analysed on VAX-Ⅱ using SAS statistical software series.The results showed that:amongthe four groups there was no significant difference in pretreated values of each parameter,andin values of PT,KPTT,AT-Ⅲ:Ag and α_2-MG at the same sampling occasion.The effects ingroup Ⅱ(50mg×6)were more significant as compared with those in other three groups:valuesof Ⅶ:C,Ⅷ:C were obviously lower than those in group I(50mg)and Ⅲ(200mg).Moreover,VWF levels in group Ⅱ and IV(600mg)were significantly lower as compared withthose in other two groups.So the results suggested that the autiprogestin given in multiple low doses(50mg×6)hadmore evident effects on coagulation and fibrinolysis than in single high dose(600mg)as usedfor induced abortion.The snthetical effect tended to inhibit coagulant activity,as considering it with the clinical course,however,these effects were not the main cause leading to heavy bleeding or prolonged bleeding.