转化生长因子α和表皮生长因子在恶性肿瘤的表达

Expression of Transforming Growth Factor-alphaand Epidermal Growth Factor in Patientswith Malignant Tumors

目的:探讨转化生长因子(ＴＧＦ－α)和表皮生长因子(ＥＧＦ)在恶性肿瘤患者中表达的临床意义。方法:采用放射免疫方法,以健康体检者为对照,检测２０６例中晚期恶性肿瘤患者血清ＴＧＦ－α和ＥＧＦ水平。结果:恶性肿瘤患者血清ＴＧＦ－α与ＥＧＦ都有高表达,与对照组相比有显著性差异(Ｐ＜０．０１),肝癌和乳腺癌组ＴＧＦ-α水平较其它肿瘤组增高(Ｐ＜０．０５),而各肿瘤组ＥＧＦ水平无差异,这可能与肝癌患者ＴＧＦ－α自分泌循环有关;有远处转移癌组ＴＧＦ－α水平高于无远处转移癌组(Ｐ＜０．０１),而ＥＧＦ水平则无差异,说明ＴＧＦ－α表达与肿瘤分期有关。结论:ＴＧＦ－α与ＥＧＦ在许多肿瘤中出现过度表达,ＴＧＦ－α和ＥＧＦ的表达状况可作为肿瘤及肿瘤恶性程度的标记物,ＴＧＦ－α还可作为判断肿瘤临床分期的一个重要指标。

ve: To evaluate the clinical significance of the expression of transforming growth factor-alpha (TGF-α) and epidermal growth factor (EGF) in patients with malignant tumors. Methods: Radiation immunoassay was used to determine the levels of TGF-α and EGF in 206 cases of malignant tumors, and the results were compared with those on healthy people. Results: The serum levels of TGF-a and EGF were sighificantly increased in patients with malignant tumors, compared to those of the control group (P<0.01). In the liver cancer group and breast cancer group,the serum levels of TGF-a were higher than that in the other groups (P <0.05). The serum level of EGF was not significant different among different tumor groups. The serum level of TGF-α was significantly higher in metastatic tumor group than that in non-metastatic group, indicating the correlation of tumor stage with the expression of TGF-α. Conclusion: The results suggest that the serum levels of TGF-α and EGF are highly expressed in malignant tumors. TGF-α and EGF could be used as markers of tumor and the malignancy of tumor. TGF-α may also serve as an important indicator of clinical stage of tumor.