泰安市新生儿先天性甲低调查研究

Analysis of screening for congenital hypothyroidism in neonates of Taian City

目的 研究泰安市先天性甲低的发病率及分布情况 ,以减少残疾儿的发生率和提高人口素质 ,分析先天性甲低筛查的经济效益、社会效益。方法 应用ELISA进行大样本初筛 ,TSH高于切值者进行RIA确诊 ,对先天性甲低患儿给甲状腺片 2～ 9mg/kg/d治疗。结果 1999.6～ 2 0 0 0 .12筛查 82 63 8例新生儿 ,确诊先天性甲低 18例 ,17例患儿接受治疗。结论 本研究显示先天性甲低分布以肥城、宁阳、新泰发病率高 ,泰山区、岱岳区发病率低 ;农村发病率高 ,城市发病率低。新生儿先天性甲低筛查具有良好的经济效益、社会效益 ,本病治疗效果良好。

Objective: To study the incidence and distribution of congenital hypothyroidism(CH) in neonates of Taian City in order to reduce the incidence in the defective children and improve the population quality, and analyse the economic and social value in screening of CH. Methods: ELISA was used for initial screening, and the patients over cut off were diagnosed by RIA. Thyroid Tab. 2～9 mg/kg/d were given to patients of CH. Results: Eighteen patients of CH were diagnosed in the screening of 82638 newborns and seventeen patients were treated. Conclusion: The study demonstrates higher incidences in Feicheng, Ningyang and Xintai, but lower in the districts of Taishan and Daiyue in the distribution of CH. The incidence is higher in the countryside than in the city. The screening of CH in neonates is economically and socially valuable. And the treatment of CH is effective.