三组不同的联合化疗方案治疗晚期胃腺癌病例的比较

Comparative Study of Three Different Chemotherapies for Advanced Gaster Adenocarcinoma

目的 比较三组不同的联合化疗方案对晚期胃癌的疗效和毒性。方法 对ECF方案、FAMTx方案、FAM方案治疗的 77例晚期胃腺癌病例的临床资料统计分析。结果 ECF组有效率为 6 1.5 % (16 / 2 6 ) ,其中完全缓解 2例 ;FAMTx组有效率为 5 2 % (13/ 2 5 ) ,其中完全缓解 1例 ;FAM组有效率为 34.2 % (9/ 2 6 )。毒副作用主要为骨髓抑制、肾功能不全、脱发及粘膜炎。

Objective To compare the efficacy and toxicity of three different chemotherapies for advanced gaster adenocarcinoma. Methods The clinical data of cases with advanced gaster adenocarcinoma (1)epidoxorubicin plus cisplatin plus fluorouracil plus leucovorin (ECF, 26 cases),(2)fluorouracil plus doxorubicin plus methotrexate (FAMTx,25 cases), and (3)fluorouracil plus doxorubicin plus mitomycin (FAM,26 cases) were analysed. Results The response rate was 61.5% in patients treated with ECF ,52% in those treated with FAMTx,and 34.2% in those treated with FAM respectively.The major toxic reactions in the three groups were tolerable myelo-supprescion ,renal insufficiency, hair loss and mucous membrane inflammation. Conclusion ECF and FAMTx are effective and safe chemotherapy for the treatment of advanced gaster adenocarcinoma.