幽门螺杆菌感染胃部病变的随访研究

Long-term sequelae of Helicobacter pylori gastritis

目的探讨幽门螺杆菌(Hp)感染在胃癌发生发展中所起的作用。方法应用队列研究的方法随访样本人群的胃部病变情况的变化及饮食、生活等方面的情况,并调查胃癌的发生情况。结果943例患者中,Hp阳性率为61.4%,随访期为5～10年,平均5.5年,失访率为18.98%。其中阳性队列中发现胃癌23例(胃癌的发生率为5.7%,23/403),而阴性组确诊胃癌7例(2.2,7/324),两组差异有显著性(p=0.017)。结论幽门螺杆菌感染与胃癌的发生关系密切。

Objectives:To explore the role of H.pylori infection on gastric carcinoma development by using cohort method and long time follow up of large size of population.Methods:This was a retrospective cohort study on the same population.The changes of the gastric diseases,dietary,living status of these enrolled samples were followed up since the enrollment day.The progression of gastric carcinoma development was also recorded.Results:Among all the 943 eligible patients,H.pylori positve rate was 61.4%.The follow up period range was 5 to 10 years with average of 5.5 years.The final complete olst rate was 18.98%.Twenty three gastric carcinoma cases were found in H.pylori(+) cohort(raw occurrence rate 5.7%),and 7 cases in H.pylore(-) cohort(2.2%).The difference was quite significant(P=0.017).Conclusion:Helicobcter pylori infection is colsely associated with gastric carcinoma development.