HGF/SF、TGF-β_1、NO在动脉硬化闭塞症发病中的意义

The significance of HGF/SF,TGF-β_1 and NO in the pathogennesis of atheriosclerosis obliterans

目的 :探讨肝细胞生长因子 /扩散因子 (HGF/SF)、转化生长因子 β1(TGF β1)、一氧化氮 (NO)与动脉硬化闭塞症 (ASO)之间的关系 ,阐明HGF/SF等在ASO发病及疾病进展和预后中的临床意义。方法 :ASO组 6 0例 ,其中间歇性跛行组 30例 ,静息痛组 18例 ,坏疽组 12例。分别检测外周血中的HGF/SF、TGF β1、NO等指标 ,同时应用血管扫描测量患肢的踝肱指数 (ABI)和动脉闭塞程度。 6～ 12月后随访 ,复查各项指标。结果 :ASO组HGF/SF和NO显著低于对照组 (P <0 0 1,P <0 0 5 ) ,且与病情严重程度一致 (间歇性跛行组 >静息痛组 >坏疽组 ) ;TGF β1升高 (P <0 0 1) ,HGF/SF与TGF β1显著负相关 (γ = 0 6 6 12 ,P <0 0 1)。ASO伴糖尿病患者HGF/SF降低极显著 (P <0 0 1)。随访表明HGF/SF与疾病的预后密切相关 ,低HGF/SF预后不良。结论 :HGF/SF、TGF β1及NO参与了ASO的发生发展 ,HGF/SF是判断ASO病期、反映内皮细胞功能的可靠指标。

Objective: In order to investigate the relationship between hepatocyte growth factor/scatter factor(HGF/SF),nitric oxide(NO),transforming growth factor-β 1(TGF-β 1)and atheriosclerosis obliterans(ASO).Methods: 60 cases of ASO were divided into three groups according to the severity:the intermittent claudation group(30 cases),the rest pain group(18 cases)and gangrene group(12 cases).HGF/SF,TGF-β 1,NO and Ankle-Brachial index(ABI)were determined in the patients and normal controls(30 cases)respectively.Results: HGF/SF and NO in the patients were significantly lower in ASO than in normal controls(P<0 01,P<0 05)and the levels were significantly decreaesd with the severity increased,but the TGF-β 1 on the contrary.There was a powerful negative correlation between HGF/SF and TGF-β 1 (γ=-0 6612,P<0 01).ASO with diabetes had a lower HGF/SF,NO and ABI but a higher TGF-β 1.The follow-up showed bad results with lower HGF/SF.Conclusion: HGF/SF and TGF-β 1 might play an important role in the pathogenesis of ASO,and can be a good reference for judging the severity and early diagnosis parameter of ASO.