结直肠癌微血管密度与生物学行为及预后相关性研究

The expression of MVD in colorectal carcinoma and its clinical significance

目的 :探讨微血管密度 (MVD)与结直肠癌淋巴结转移及预后的相关性及其临床意义。方法 :应用免疫组化S P法 ,以Ⅷ因子相关抗原作为血管内皮细胞标记物测定其微血管密度。结果 :5 9例结直肠癌中 ,淋巴结转移组MVD高表达 ,无淋巴结转移组MVD低表达 (P <0 0 5 )。MVD低表达组 5年生存率明显高于MVD高表达组 (P <0 0 5 )。 33例患者术中施行门脉插管术后接受 5 Fu化疗 ,5年生存率MVD低表达组与MVD高表达组无统计学差异 (P >0 0 5 )。术后未加辅助治疗 2 6例 ,5年生存率MVD低表达组明显高于MVD高表达组 (P <0 0 5 )。结论 :MVD表达与结直肠癌的生物学行为及预后密切相关 。

To evaluate the expression of microvessel density(MVD) in colorectal carcinoma and its clinical significance.Methods:The Ⅷ Rag expression was measured by S P immunohistochemical method.MVD in the colorectal carcinoma tissue was assayed.Results:Of the 59 cases of colorectal carcinoma studied, MVD was higher expressed in carcinoma with lymph node involvement than that without lymph node involvement(P<0 05).The analysis demonstrated that the 5 year survival rate in patients with lower MVD expression was better than that of those with higher MVD expression.Conclusion:The expression of microvessel density has a significant correlation to the biological behavior and prognosis of patients with colorectal carcinoma (P<0 05). keywirds