摘要
目的 探讨Th1/Th2 网络因子失衡在红斑狼疮、多形性日光疹发病中的作用。方法 应用酶联免疫吸附法 (ELISA)测定了 2 4例系统性红斑狼疮 (男 2例 ,女 2 2例 ) ,16例多形性日光疹病人 (男 9例 ,女 7例 ) ,15例健康对照者 (男 8例 ,女 7例 )外周血中白介素 - 1α(IL -Iα) ,白介素 - 1β(IL - 1β) ,白介素 - 6 (IL - 6 ) ,白介素 - 6受体 (sIL - 6R) ,白介素 - 8)IL - 8)和肿瘤坏死因子 -a(TNF -a) 6种细胞因子。结果 SLE病人血清中辅助T细胞I型 (Th1)细胞因子TNE -α、IL - 8水平升高 ,辅助T细胞II型 (Th2 )细胞因子IL - 6、sIL - 6R的水平高于正常对照。PLE病人血清中辅助T细胞I型 (Th1)细胞因子IL -Lα,IL - 8的水平高于正常对照。结论 在SLE病人中Th1、Th2 型细胞因子的水平均有不同程度的升高 ,在PLE病人血清中 。
Objectives To discover the pathogenesis of cytokines network in patients with systemic lupus erythematosus(SLE)and polymorphous light eruption (PLE).Methods We measured the serum concentration of interleukin(IL-Iα),interleukin(IL-1β),interleukin(IL-6),interleukin(IL-6 receptor),interleukin(IL-8),tumor necorsis factor-alpha(TNF-α)from patients with active SLE(male:2 cases,female:22 cases),16cases of PLE(male:9 cases,female:7 cases),15 cases of healthy control(male:8 cases,femal:7 cases)by enzyme-linked immmunosorbent assay(ELISA)method.Results Our study showed:1.The serum concentration of TNF-α、IL-8 of Th 1 type,IL-6、sIL-6R of Th 2 type in SLE patients were significantly higher than that of controls.2.The serum level of IL-1α、I1-8 of Th 1 type in PLE patients were higher than that of contrles.Conclusions The expression of Th 1 and Th 2 type cytokines of SLE are up-regulation.The serum levels of Th 1 type cytokines of PLE increase.The study supports the possible role of the cytokine network in SLE and PLE.
出处
《皮肤病与性病》
2004年第4期1-2,共2页
Dermatology and Venereology
基金
中华医学会皮肤科学会青年科研基金资助课题
