新凝灵与垂体后叶素治疗门脉性肝硬化并发上消化道出血的疗效比较

Comparison of Therapeutic Effects between Ethylenediamine Diaceturate and Pituitrin on Upper Digestive Tract Hemorrhage Resulting from Portal Cirrhosis of Liver

目的 比较新凝灵与垂体后叶素治疗门脉性肝硬化并发上消化道出血的疗效。方法 选择门脉性肝硬化并发上消化道出血 5 6例 ,随机分为 2组 ,新凝灵组 3 0例 ,男性 2 0例 ,女性 10例 ,年龄 (5 0± 6)岁 ,新凝灵 60 0mg ,静滴 1次 /d ,连用 4～ 5d ;垂体后叶素组 2 6例 ,男性 18例。女性 8例 ,年龄 (4 9± 16)岁 ,垂体后叶素 10 0U加入 10 %葡萄糖 5 0 0ml中持续静滴 ,速度 0 .2U/ml·min- 1 ,连用 3～ 5d。结果 新凝灵组 3 0例全部止血成功 ,垂体后叶素组 2 6例 ,只有 2 2例止血成功 ,两组止血成功率比较 ,新凝灵组优于垂体后叶素组 (P <0 .0 5 )。便潜血转阴天数及住院天数 ,新凝灵组分别为 (5 14± 1 2 )d ,(12 .0± 1.6)d ,而垂体后叶素组分别为 (6.7± 1.4)d ,(15 .8± 1.4)d。两组便潜血转阴时间与住院时间相比 ,新凝灵组均少于垂体后叶素组 (P均 <0 .0 1)。结论 应用新凝灵静滴治疗门脉性肝硬化并发上消化道出血 ,在止血效果、输血量、住院天数、大便潜血转阴等方面 ,明显优于垂体后叶素。

Objective To compare the therapeutic effects between ethylenediamine diaceturate and pituitrin on upper digestive tract hemorrhage resulting from portal cirrhosis of liver. Methods Fifty-six patients suffering from upper digestive tract hemorrhage resulting from portal cirrhosis of liver were divided into two groups at random, i.e. ethylenediamine diaceturate group (30 ones, 20 male, 10 female, aging at 50±16) and pituitrin group (26 ones, 18 male, 8 female, aging at 49±16) which were respectively administered with daily 600mg of ethylenediamine diaceturate through intravenous drip for 4～5 days and 100U pituitrin for 3～5 days.Results All the patients succeeded in stopping bleeding in ethylenediamine diaceturate group and only 22 ones succeeded in pituitrin group, which suggested significant difference between them (P<0.05). They also differed in some aspects such as the hospitalizing period and the days in which occult blood in the feces became negative, i.e. the former group had better therapeutic effect (P<0.01). Conclusion It is more helpful to apply ethylenediamine diaceturate to upper digestive tract hemorrhage resulting from portal cirrhosis of liver than pituitrin.