善得定与垂体后叶素治疗肝硬化并发上消化道出血的疗效比较

Comparison between the Therapeutic Effects of Octreotide and Pituitrin on Upper Digestive Tract Bleeding Caused by Hepatocirrhosis

目的 比较奥曲肽 (善得定 )与垂体后叶素对肝硬化并发上消化道出血的止血效果。方法 将 60例肝硬化并发上消化道出血的患者随机分为两组。治疗组 3 1例 ,首次给善得定 10 0 μg静推 ,然后以 2 0 μg/h ,静滴 ,持续 48～ 96h ;对照组 2 9例 ,首次静推垂体后叶素 10IU ,继之以 0 1～ 0 3IU/min静滴 ,持续 48～ 96h ,其他治疗两组相同。结果 治疗组有效 2 9例 ,有效率为 93 5 % ,出现副反应 3例 ,副反应发生率为9 7%。对照组有效 2 1例 ,有效率为 72 4% ;出现副反应 11例 ,副反应发生率为 3 7 9%。结论 对肝硬化并发上消化道出血 ,善得定的效果显著优于垂体后叶素。

Objective To compare the effects of octreotide and pituitrin on upper digestive tract bleeding caused by hepatocirrhosis. Methods Sixty patients with hepatocirrhosis complicated with upper digestive tract bleeding were divided into two groups, i.e. treating group (31) and control group (29) that were respectively administered with octreotide at 20μg/h and pituitrin at 0.1～0.3IU/min for 48～96 hours via intravenous drip. Other treatment was the same for the two groups.Results There were 29 patients (93.5%) who reached effect to some extent and 3 ones (9.7%) who suffered from side reactions in the treating group. But in the control group, the numbers were respectively 21 (72.4%) and 11 (37.9%). There were significant differences between the two groups (P<0.05). Conclusion Octreotide possesses more ideal effect on upper digestive tract bleeding caused by hepatocirrhosis than pituitrin.