摘要
本文叙述采用冷却速度控制过饱和度,研究甲芬那酸在二甲基甲酰胺溶剂中的结晶规律,寻求影响产物密度和粒度的因素,总结出使甲芬那酸密度达到0.8g/cm3以上的优惠条件是冷却降温速率在9-12℃/h之间,结晶溶液中结晶粒子的雷诺数Re应该接近100。这些数据可以作为工艺过程和工程设计的参考依据。
In order to get eligible crystal of mefenamic acid whose apparent rapped density (ARD) should be over 0. 8g/cm3, the crystallization regularity for mefenamic acid in dimethylformamide solvent is studied by gradually cooling to control the cooling rate of crystallizing solution e. g. to control the supersaturation. The experiment result shows that the cooling rate is within 9 - 12 ℃/h and the stirring intension in crystallizer is that the Reynolds' number (Re) of particles must approach 100. It is profitable for processing and engineering design.
