急性粒细胞性白血病预后因素分析

Analysis of Prognostic Factors in Children with Acute Myeloid Leukemia

目的 探讨儿童急性粒细胞性白血病 (AML)预后的相关因素。方法 回顾分析AML 84例患儿多种因素与 3年长期无病生存率 (EFS)的关系 ,并进行统计学分析。结果 3年EFS为 47.6 % ,统计学分析包括性别、FAB分型中M3型和M5型、ETO阳性M2 、PML RAR阳性M3型、1个月时骨髓未缓解、复杂异常型染色体等 ,其 3年EFS与对照组比较有显著性差异(P均 <0 .0 5)。结论 儿童AML的EFS与发病时多种因素有关。其中男童、M5型、1个月时骨髓未缓解、复杂异常型染色体为预后差的相关因素。ETO阳性M2 、PML RAR(+)的M3型预后好。

Objective To analyze prognostic factors in children with acute myeloid leukemia(AML).Methods Retrospective analyze the relationship between many factors of the diagnosed children with AML and their 3-years event-free survival(EFS).Statistics was analyzed with χ2 test.Results The 3-years EFS was 47.5%.According to the analysis of statistics,EFS of some children groups had statistical differences with their controls (P<0.05),which included sex,M 5 type,M 3 type,M 2 of ETO positive,M 3 of PML-RAR positive,not complete response(CR) to induction in 1 month,complex abnormal karytypes.Conclusions The EFS of children with AML have relationships with many factors.Male,M 5 type,not CR in 1 month and complex abnormal karytypes are bad factors to survive.M 2 type of ETO positive and M 3 type of PML-RAR positive are good factors.