组织细胞坏死性淋巴结炎9例

Clinical Analysis of 9 Cases with Histiocytic Necrotizing Lymphadenitis in Children

目的 通过对 9例小儿组织细胞坏死性淋巴结炎 (HNL)进行总结分析 ,探讨其诊断和治疗方法。方法 回顾性分析 1 999年 8月～ 2 0 0 3年 7月住院治疗 9例HNL的临床及病理学资料。结果 所有病例均有发热和颈部淋巴结大。淋巴结活检可见典型的病理和免疫组化改变。 6例应用肾上腺皮质激素治疗 ,疗程为 3～ 6个月 ,疗效显著 ,复发病例少。结论 该病临床表现缺乏特异性 ,需早期进行淋巴结活检 ,根据病理和免疫组化进行诊断 ,并早期予肾上腺皮质激素治疗。较长疗程的激素治疗可能有助于减少复发。

Objective To summary 9 cases of histiocytic necrotizing lymphadenitis(HNL) of children and discuss the diagnosis and therapy.Methods Reviewed clinical data and histological findings.Nine cases of HNL from 1999 to 2003 years.Results All patients had fever and swelling of lymph node on neck.They were diagnosed by lymph node excisional biopsy.Six cases were administrated of glucocorticoid and benefited significantly.Conclusions The etiological factor and pathogenesis is unknown,yet.The clinical situation is not characterful.The diagnosis is always established by histopathology. The effect of management using glucocorticoid is remarkable.A long course can probably decrease recurrence.