慢性乙型肝炎患者干扰素治疗前后血清可溶性细胞间粘附分子-1水平变化

Serum levels of soluble intercellular adhesion molecule-1 in chronic hepatitis B patients treated with interferon

目的 观察干扰素 - α1b(IFN- α1b)治疗慢性乙型肝炎患者前后血清可溶性细胞间粘附分子 - 1(s ICAM- 1)水平变化。方法 对慢性乙型肝炎治疗前行肝穿活检术 ,治疗前和治疗 6个月后 ,采用酶联免疫吸附方法 ,检测血清可溶性细胞间粘附分子 - 1的水平 ,观察干扰素对慢性乙型肝炎患者的疗效、干扰素疗效与肝组织炎症活动度的关系。结果 IFN-α1b治疗后呈完全应答者4 5 .6 %、部分应答者 2 6 .1%、无应答者 2 8.3% ;肝组织炎症活动度为 G3者 ,干扰素治疗慢性乙型肝炎的疗效为 72 .2 %、G4者为75 .0 % ;完全应答者与部分应答者 ,治疗前后血清 s ICAM- 1水平的变化有显著性差异 (P<0 .0 1)。结论 IFN- α1b可调控肝细胞表达 ICAM- 1,动态监测血清中 s ICAM- 1水平的变化 ,对评判干扰素抗乙肝病毒的疗效有一定的临床意义。

Objective To investigate the serum levels of soluble intercellular adhesion molecule-1(sICAM-1) in chronic hepatitis B patients treated with interferon-α1b.Methods The needle biopsy of liver were performed in chronic hepatitis B patients before treatment.The serum levels of sICAM-1 were detected by ELISA before and after 6 months treatment. The observation result of chronic hepatitis B patients treated with interferon and relations between effect of interferon and inflammation activity were done. Results The full response rate was 45.6%, partial response rate was 26.1%, non-response rate was 28.3% in post-treatment. Inflammation activity of liver was G3, the response rate was 72.2% after IFN-α1b treatment, correspondence G4, the response rate was 75.0%. There were significant difference in the serum levels of sICAM-1 in pre-treatment and post-treatment between full response and partial response(P<0.01).Conclusions These results suggest IFN-α1b can regulate the expression of ICAM-1 in the liver cells . Detecting the serum levels of sICAM-1 to judge the effect of the IFN antivirus on patients with hepatitis B may be important clinical significance.