期刊文献+

细胞因子介导的2型糖尿病β细胞损伤机制 被引量:10

下载PDF
导出
摘要 胰岛 β细胞损伤是 2型糖尿病的重要发病机制。近年研究发现细胞因子白介素 (IL) 1β、肿瘤坏死因子 (TNF) α、干扰素 (IFN) γ、IL 6、瘦素等可通过不同途径直接或间接参与 2型糖尿病 β细胞损伤。一氧化氮、核因子κB等在细胞因子介导的β细胞损伤中起重要作用。
出处 《国外医学(内分泌学分册)》 2005年第1期13-15,共3页 Foreign Medical Sciences(Section of Endocrinology)
  • 相关文献

参考文献2

二级参考文献18

  • 1Asfari M, Janjic D, Meda P, et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology,1992,130 : 167-178.
  • 2Hohmeier HE, Thigpen A, Tran VV, et al. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1β-induced cytotoxicity and reduces nitric oxide production. J Clin Invest, 1998,101 : 1811-1820.
  • 3Stephens LA, Thomas HE, Ming L, et al. Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells. Endocrinology, 1999,140:3219-3227.
  • 4Swift S, Lorens J, Achacoso P, et al. Rapid production of retmviruses for efficient gene delivery to mammalian cells using 293T cell-based systems. Current Protocols in Immunology, 1999:31.
  • 5Rabinovitch A. An update on cytokines in the pathogenesis of insulindependent diabetes mellitus. Diabetes Metab Rev, 1998,14:129-151.
  • 6Pahl HL. Activator and target genes of Rel/NF-κB transcription factors.Oncogene, 1999,18:6853-6866.
  • 7Xiao G, Harhal EW, Sun SC. NF-κB-inducing kinase regulates the processing of NF-κB2 pl00. Mol Cell, 2001,7:401-409.
  • 8Goodbourn S, Didcock L, Randall RE. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J General Virol, 2000, 81:2341-2364.
  • 9Stephens LA, Thomas HE, Kay TWH. Protection of NIT-1 pancreatic β-cell from immune attack by inhibition of NF-kB. J Autoimmunity,1997,10:293-298.
  • 10Hotamisligil GS. The role of TNFα and TNF receptors in obesity and insulin resistance. J Int Med, 1999, 245:621-625.

共引文献26

同被引文献131

引证文献10

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部