恶性肿瘤相关性肌炎/皮肌炎20例临床分析

Clinical analysis of 20 patients with polymyositis/dermatomyositis associated with malignancy

目的 了解多发性肌炎 /皮肌炎 (PM/DM)合并肿瘤的临床相关因素 ,以利于肿瘤的早期发现。方法 回顾性分析我院 1996～ 2 0 0 3年 15 0例临床资料完整的PM/DM病例 ,对合并肿瘤与非合并肿瘤组间进行比较 ,采用t检验和 χ2 检验进行分析。结果 发生恶性肿瘤者 2 0例 ,男 13例 ,女 7例 ,平均发病年龄 5 1.84岁± 13 .93岁。多发性肌炎 65例 ,发生恶性肿瘤者 5例 ;皮肌炎 85例 ,发生恶性肿瘤者 15例。发病年龄、性别、心脏受累及癌胚抗原阳性在两组比较差异有显著性(P <0 .0 5 )。结论 PM/DM易合并恶性肿瘤 ,年龄、男性、心脏受累与癌抗胚原阳性为合并恶性肿瘤的主要临床相关因素。

Objective To identify correlative factors for early diagnosis of patients with dermatomyositis (DM) and polymyositis (PM) associated with tumor.Methods One hundred and fifty patients with PM/DM,enrolled in our department from 1996 to 2003,were retrospectively study.The data from PM/DM patients associated with tumor and not associated with tumor were statistically analysed.Results Twenty patients (5/65 with polymyositis and 15/85 with dermatomyositis) were found to be associated with a wide range of tumors,including 13 males and 7 females with the mean age of 51.84±13.93 years old at onset.There was a significant difference of age at onset,gender (male),heart involvement and the positive rates of carcino-embryonic antigen between the two groups (P<0.05).Conclusion It was found that the polymyositis/dermatomyositis patients were easily associated with a wide range of malignant tumors,and the age,gender(male),heart involvement and the positive rates of the carcino-embryonic antigen were mainly important correlation factors in clinic.