SQA鳌合盐的急性毒性和致突变性研究

Study on the Acute Toxicity and Mutagenesis of SQA

目的 检测稀土壳糖胺 (SQA)鳌合盐的急性毒性和致突变性。方法 采用霍恩氏法进行急性经口毒性试验 ,采用小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验和Ames试验对受试物进行致突变性研究。结果 SQA鳌合盐的经口LD50 >10 0 0 0mg/kg体重 ;小鼠骨髓嗜多染红细胞微核试验显示无诱发微核作用 ,小鼠精子畸形试验未见精于畸形率增高 ,Ames试验在加和不加S9条件下均无致突变性。结论 SQA鳌合盐属实际无毒级物质 ,在该实验条件下 ,无致突变作用。

To study the acute toxicity and of SQA. Oral acute toxicity test was carried out according to Horns method; micronucleus test, sperm deformation test and Ames test were carried out for mutagenic observation. SDA oral LD 50 > 10 000 mg/kg; micronucleus test indicated no mutagenic effects; no increase in sperm deformation was found in sperm deformation test; Ames test showed no mutagenic effects under the condition of both with and without S9. [Conclusion] SQA belongs to nontoxic compound and has no mutagenic effects under certain experimental condition.