电子束CT扫描检测成人2型糖尿病患者冠脉钙化的意义

Significance of electron-beam tomography for coronary calcium in adult type 2 diabetes mellitus

目的:应用电子束CT(EBT)心脏扫描,了解2型糖 尿病患者冠脉钙化的发生情况并评价EBT在判断2型糖尿病 冠脉病变中的应用价值.方法:94例受试者行心脏EBT扫 描,计算冠脉钙化发生率、钙化积分,同时收集血糖、糖化血红 蛋白(HbA1c)、血脂等相关临床信息,分析钙化积分与各临床指标间的关系.结果:糖耐量受损组、糖尿病组、冠心病组 冠脉钙化发生率较正常对照组有明显升高(93.3%,96.4%, 90.9%vs56.0%,P<0.01),钙化积分有明显升高趋势. Spearman相关分析,发现钙化积分与年龄有明显相关(r= 0.423,P<0.01).结论:2型糖尿病患者有明显的冠脉钙化, EBT钙化积分需结合其他指标共同判断冠脉病变.

AIM: To assess the prevalence and risk factors for coronary artery calcification (CAC) by electron beam tomography (EBT) in adults with established type 2 diabetes. METHODS: A total of 94 subjects aged 36-78 years underwent cardiac EBT with CAC incidence and calcium scoring. Laboratory evaluations of 75 g oral glucose tolerance test (OGTT), HbA1c, triglyceride, total cholesterol were performed. The correlation of score with age and other clinical evidence was analyzed. RESULTS: The incidence of CAC in impaired glucose tolerance (IGT) (93.3%) , Diabetes (96.4%) and coronary artery disease (CHD) (90.9%) groups was significantly (P<0.01) higher than that in normal controls. The score of CAC in IGT, diabetes and CHD groups, though with statistical significance, was also higher. CAC was found to be correlated with age (r=0.423, P<0.01). CONCLUSION: Our data suggest a prevalence of CAC in those with type 2 diabetes. But the score of CAC should be used together with other parameters of EBT in diagnosing CAD.