降植烷诱导大鼠类风湿关节炎模型的建立

Establishment of experimental animal model of pristane induced rheumatoid arthritis in rats

目的用降植烷(pristane)免疫Lewis大鼠诱导关节炎,建立类风湿关节炎(RA)动物模型。方法采用组织病理学和X线摄片的方法观察大鼠的发病程度和病理特点。结果大鼠关节炎发病率为62.5%,主要累及远端关节,关节炎症状呈慢性反复及进行性加重。关节X线摄片及病理显示关节滑膜增生、软骨组织及骨组织呈典型的关节炎病变。结论Pristane诱导关节炎()大鼠模型与人类PIARA发病及病理特点极为相似,是研究RA较理想的模型。

Objective The animal model of rheumatoid arthritis was established in Lewis rats by a single intradermal injection of pristane. Methods The degree of pathogenicity and the pathological characteristics were assayed by histiopathological techniques and joint roentgenography. Results The incidence of arthritis in rats immunized by pristane was 62.5%. Peripheral joints were mainly involved. A chronic relapsing and progressive arthritis was developed.As showed by histopathology and roentgenography, typical arthritis pathology such as synovial proliferation, articular cartilage and bone erosien were found. Conclusion Pristane induced arthritis mirrors human rheumatoid arthritis and is a very good animal model for rheumatoid arthritis.