妊娠期糖尿病孕妇静脉血、脐静脉血、胎盘瘦素水平的研究

目的 探讨瘦素与妊娠期糖尿病的关系。方法 采用放免法测定 34例妊娠期糖尿病患者和 4 6例正常产妇产前外周静脉血清、脐静脉血、胎盘瘦素水平。结果 妊娠期糖尿病组产前外周静脉血清、脐静脉血、胎盘瘦素水平均显著高于正常妊娠组。正常妊娠组胎盘瘦素与孕母血清瘦素水平存在正相关 ;而在妊娠期糖尿病组 ,产前外周静脉血清、脐静脉血、胎盘瘦素水平、产前孕妇体重指数、胎儿出生体重间均无相关关系。结论 在正常妊娠中 ,胎盘是孕期母体瘦素增加的重要来源 ;瘦素的胎儿循环独立于母体。妊娠期糖尿病孕妇、胎儿均存在高瘦素状态 ;胎盘瘦素可能非孕妇瘦素的主要来源。高瘦素状态对其发病有重要关系。

Objective: to investigate the relationship between leptin and gestational diabetes;Methods: leptin in peripheral serum and umbilical veins and placentas were measured in 34 GSM(gestational diabetes) cases and in 46 normal pregnancy cases by RIA (radioimmunoassay) method respectively. Results: leptin levels in peripheral serum and umbilical veins and placentas are higher in GSM than in normal pregnancies. placental leptin correlates leptin in peripheral serum positively in normal pregnancy. No similar correlation is found in GSM group ,leptins in peripheral serum and umbilical veins and placenta have no correlation each other and have no correlation with BMI (body mass index) or birth weight in GSM. Conclusion placenta may be the one of the souces of leptin in normal pregnancy mother. Leptin level are significantly higher in GSM, placental leptin may not be the main souce of leptin in mother. high leptin level may contribute to the progress of GSM.