疣状癌16例临床及病理分析

Sixteen cases of verrucous carcinoma: clinical and pathological features

目的:探讨男性口腔、足部及阴茎部位疣状癌的临床及组织病理学特点。方法:对16例临床拟诊为疣状癌的男性患者,采取多点、多次组织病理检查;对经组织病理检查确诊为疣状癌的患者,采取外科手术切除等措施进行根治性治疗,并对组织块进行人乳头瘤病毒(HPV)定性检测。结果:经组织病理检查证实,16例患者均为疣状癌,其中9例患者HPV阳性。14例患者经手术治疗,9例术后随访1～2年无异常发现;1例术后14个月发生腹股沟淋巴结转移,1例术后23个月局部复发。1例未治疗患者4个月后发生腹股沟淋巴结转移;另有3例失访。结论:疣状癌是一种恶性肿瘤,应该早期诊断,早期进行外科根治性治疗,术后应定期随访。

Objective: To describe and explore the clinical and pathological features of verrucous carcinoma on oral cavity, foot and penis in male patients. Methods: Different parts of biopsy specimens were examined for many times in 16 suspected male patients with verrucous carcinoma. After the diagnosis of verrucous carcinoma was confirmed, radical therapy was given, and the HPV was detected. Results: The diagnosis of verrucous carcinoma in sixteen cases was confirmed by pathology. The HPV was detected in 9 of them. The lesions were excised in 14 cases and 9 cases with satisfactory effects. The metastasis of regional nodes was found in 1 case 14 months after operation, and in another case 4 months later without treatment. Relapse in inguinal region was identified in one case 23 months after operation. Three cases failed to be followed up. Conclusions: Verrucous carcinoma is a kind of malignant tumor. Early diagnosis is important. Radical therapy should be given earlier and follow-up should be ensured.