突发性耳聋患者血浆SOD LPO TXA_2 PGI_2水平与行为类型

RELATIONSHIP BETWEEN TYPE OF BEHAVIOR AND SOD,LPO,TXA_2,PGI_2 IN SUDDEN DEAFNESS

目的 探讨突发性耳聋患者的行为类型及发病机理。方法 调查了 15 2例突发性耳聋病人和170例正常人的行为类型 ,并测定了其血浆SOD ,LPO ,TXA2 ,PGI2 水平。结果 突发性耳聋病人A型性格为 6 8.4 2 % ,而健康对照则为 4 7.6 5 % (P <0 .0 1)。突发性耳聋患者不论是A型性格还是B型性格血清SOD、6 -keto -PGF1α均显著低于对照组 (P <0 .0 1) ,而LPO、TXB2 含量则高于对照组 (P <0 .0 1) ;突发性耳聋患者及对照组组内A型性格血浆TXB2 均显著高于B型性格 ,A型性格 6 -keto -PGF1α则低于B型性格 (P <0 .0 5 )。LPO、SOD虽有差异 ,但无统计学意义 (P >0 .0 5 )。结论 突发性耳聋与行为类型密切相关。A行为易患突发性耳聋 ,可能与血浆高水平的TXB2 、LPO和低水平的SOD、PGI2

Objective Objective To observe the relationship between type of behavior and SOD,LPO,TXA 2,PGI 2 in 152 patients with sudden deafness.Methods In this paper, the type of behavior were investigated and the level of plasm SOD,LPO,TXA 2,PGI 2 were measured in 152 patients with sudden deafness and 170 healthy people.Results It was that the rate of A behavior was 68.42% in 152 patients and 47.65% in control group. The level of plasm LPO,TXA 2 in the patients was positively higher than that in the control group at A and B behavior (P<0.01).The level of plasm SOD,,PGI 2 in the patients was positively lower than that in the control group at A and B behavior (P<0.01).The level of plasm TXA 2 in the A behavior was positively higher than that in the B behavior at two groups(P<0.05).The level of plasm PGI 2 in the A behavior was positively lower than that in the B behavior at two groups(P<0.05).Conclusion There is a positive correlation between the A behavior and sudden deafness.