不同时间服用阿司匹林对老年原发性高血压患者血小板功能及血压的影响

Effect of aspirin administrated at different time on platelet function and blood pressure in elderly patients with essential hypertension.

目的探讨不同时间服用阿司匹林对老年原发性高血压患者血小板功能和血压的影响。方法60例老年原发性高血压患者随机分为3组,每组20例;常规治疗组(氨氯地平510mg)、阿司匹林Ⅰ组(氨氯地平+阿司匹林100mg,早晨顿服)和阿司匹林Ⅱ组(氨氯地平+阿司匹林100mg,睡前顿服),疗程4周。治疗前后测定血压、血小板聚集率、血浆中血小板α颗粒膜蛋白及血栓素B2水平。结果3组原发性高血压患者治疗后上述观测指标均明显降低(P<0.05或0.01),阿司匹林Ⅰ、Ⅱ两组血小板聚集率、血小板α颗粒膜蛋白及血栓素B2降低幅度大于常规治疗组(P<0.05),但血压降低幅度与常规治疗组比较无明显差异(P>0.05)。结论阿司匹林对老年原发性高血压患者血小板功能的影响与用药时间无关,对血压无影响。

Objective To evaluate the effect of aspirin administrated at different time on platelet activation and blood pressure(BP)in elderly patients with essential hypertension.Methods 60 elderly patients with essential hypertension were randomly divided into 3 groups: routine group(n=20,amlodipine 5-10 mg),aspirin I group(n=20,amlodipine+aspirin 100 mg,taken in the morning) and aspirin Ⅱ group(n=20,amlodipine+aspirin 100 mg,taken before bedtime).The treatment course was 4 weeks.The levels of platelet α-granule membrane protein(GMP-140),platelet aggregation rate(PAR),thromboxane B_2(TXB_2) and BP were measured before and after treatment.Results The levels of GMP-140,PAR,TXB_2 and BP were decreased(P<0.05-0.01) in 3 groups.The decreasing degree of GM-140,PAR,and TXB_2 in routine group was lower than those in aspirin Ⅰ and Ⅱ group(P<0.05).There was no difference among each indexes between aspirinⅠ and Ⅱ group(P>0.05).~Conclusion There is no relationship between administration time of aspirin and platelet activation and BP in patients with essential hypertension.