肝素对肺源性心脏病急性加重期肺动脉压及血气指标的影响

Effect of heparin on pulmonary artery pressure and blood gas indexes in the patients with cor pulmonale during acute attack.

目的探讨肺源性心脏病(肺心病)急性发作期肝素的治疗效果。方法将98例肺心病患者分为肝素治疗组和常规治疗组各49例,比较治疗前后患者肺动脉压和血气指标的变化。结果肝素治疗组治疗后肺动脉压明显降低,同时伴动脉血氧分压升高和动脉血二氧化碳分压降低;而常规治疗组上述指标虽有改善,但改善幅度远不及肝素治疗组,两组比较差异有显著性意义(P<0.01)。结论肺心病患者及时进行肝素抗凝干预治疗,可明显降低肺动脉压,改善血气指标和氧合情况,进而改善肺心病急性加重期患者的不良预后。

Objective To investigate the therapeutic effect of heparin in the patients with cor pulmonale during acute attack.Methods 98 cases of cor pulmonale were divided into heparin treatment group and routine group(n=49,each group) for the comparison of pulmonary artery pressure and blood gas before and after treatment.Results Pulmonary artery pressure in heparin treatment group was remarkably decreased while PaO_2 was increased and PaCO_2 decreased,which were slightly changed in routine group but not so remarkably compared with heparin treatment group,with significant difference(P<0.01).Conclusion Timely treatment with heparin of anticoagulation therapy can remarkably decrease pulmonary artery pressure and improve the blood gas indexes and oxygenation soas to improve the poor outcome of cor pulmonale during acute attack.