摘要
目的探讨提高Ⅲ期非小细胞肺癌治疗效果的方法。方法85例Ⅲ期非小细胞肺癌患者随机分为3组,并进行不同顺序的治疗,A组(化疗+手术+放疗)28例,放疗后配合辅助化疗;B组(手术+化疗+放疗)28例;C组(手术+放疗+化疗)29例。比较各组3年生存率、局部区域复发率和远处转移率的差异性。结果A、B、C3组3年生存率分别为75.00%,53.57%,44.83%,其中A组与C组比较差异有显著性意义(P<0.05);3组局部区域复发率分别为7.14%,32.14%,17.24%,其中A组与B组比较差异有显著性意义(P<0.05);各组远处转移率分别为7.14%,10.71%,37.93%,其中A组与C组及B组与C组比较,差异均有显著性意义(P<0.05)。结论术前化疗再手术,配合术后放疗及辅助化疗,可提高治疗Ⅲ期非小细胞肺癌的疗效。
Objective To evaluate the treatment of the curative effect to stage-Ⅲ non-small cell lung cancer(NSCLC).Methods 85 cases of stage-Ⅲ NSCLC were randomly divided into 3 groups who were treated according to different proceduse.28 cases in group A(chemotherapy +surgery+radiotherapy) were treated by assist chemotherapy after radiotherapy;Ther were 28 cases in group B(surgery+chemotherapy+radiotherapy) and 29 cases in group C(surgery +radiotherapy+chemotherapy).3-year survival rates,the rates of local relapse and distal metastasis were compared among 3 groups.Results 3-year survival rates in 3 groups were 75.00%,53.57% and 44.83%,among which there is a significant difference between group A and group C(P<0.05);The rates of local relapse were 7.14%,32.14% and 17.24%,among which there is a significance difference between group A and group B^(P<0.05) ;The rates of distal metastasis were 7.14%,10.71% and 37.93%,among which there ase significant difference between group A and group C as well as between group B and group C(P<0.05).Conclusion Preoperative chemotherapy plus surgery followed by radiotherapy may improve the outcome of stage-Ⅲ NSCLC.
出处
《中国综合临床》
北大核心
2005年第2期167-168,共2页
Clinical Medicine of China
