癌组织中VEGF-C及nm23基因蛋白表达与大肠癌浸润转移的关系

Relationship between VEGF-C, nm23 protein and invasion, metastasis of colorectal cancer

目的 探讨血管内皮生长因子c(VEGF-C)及nm23基因蛋白在大肠癌组织中的表达及其与癌局部浸润、淋巴结转移的关系。方法 采用免疫组化SP法,检测93例原发性大肠癌患者手术切除的癌组织中VEGF-C及nm23基因蛋白。结果 VEGF-C基因蛋白阳性表达率与大肠癌组织的分化程度无明显相关性(P>0.05),与癌的浸润深度、淋巴结转移呈正相关(P均<0.05)。nm23基因蛋白在大肠癌淋巴结无转移组中的阳性表达率显著高于有转移组(P<0.05)。结论 VEGF-C及nm23基因蛋白的异常表达在大肠癌的发生、发展和淋巴结转移中可能起重要作用。联合检测癌组织中VEGF-C及nm23基因蛋白,对判断大肠癌的临床分期、淋巴结转移及预后有一定的参考价值。

Objective To study the relationship between the expression of vascular endothelial growth factor-C (VEGF-C),nm23 gein protein and local invasion,lymph node metastasis of colorectal cancer. Methods Using immunohistochemical SP method, the expression of VEGF-C, nm23 gein protein were examined in 93 patients with human colorectal cancer. Results The positive expression rate of VEGF-C gein protein in coloretal cancer was not correlated with histological grade (P>0. 05). There was a significant relationship between the expression of VEGF-C and the infiltrated depth,lymph node metastasis(P<0. 05). The positive expression rate of nm23 gein protein was significantly higher in the group without lymph node metastasis than that in the group with lymph node metastasis(P<0. 05). Conclusions The unnormal expression of VEGF-C,nm23 gein protein have an important significance in development and lymph node metastasis of colorectal cancer. The examination of VEGF-C and nm23 gein protein may be useful for predicting of the clinical stage, lymph node metastasis and prognosis in the patients with colorectal cancer.