抑癌基因PTEN在口腔鳞癌中的表达及其意义

Expression and significance of PTEN in oral squamous cell carcinoma

目的 研究PTEN在口腔鳞癌组织中的表达及其临床病理意义。方法 用SP免疫组化测定 5 4例口腔鳞状细胞癌、11例不典型增生、14例正常口腔黏膜组织中PTEN蛋白的表达 ,并与组织学类型、组织学分级、淋巴转移和临床分期等生物学行为进行相关分析。结果 PTEN蛋白在口腔鳞癌、不典型增生、正常口腔黏膜高表达率为 75 9%、90 9%、10 0 % ,其表达率与组织学类型 (P <0 0 5 ) ,组织学分级 (P <0 0 5 )和淋巴结转移有关 (P <0 0 5 ) ,与口腔鳞癌中临床分期无关 (P >0 0 5 )。结论 PTEN基因抑制口腔鳞癌细胞的生长、分化及淋巴转移 ,表达的高低可作为判断预后的参考指标之一。

Objective To study the expression and clinicopathological significane of PTEN in oral squamous cell carcinoma (OSCC). Methods PTEN expreision was detected by S-P immunohistochenical methods on paraffin sections from 54 cases of OSCC, 11 of catypical hyperplasia, 14 of nomal Oral mucosa. Results Higher levels of PTEN was found in 75.9% OSCC, 90.9% catypical hyperplasia, and 100% nomal oral mucosa. In OSCC PTEN expression was significantly related to the tissue type (P<0.05),the cell grade (P<0.05)and lymph node metastasis (P<0.05), but not related to the clinical stage(P>0.05). Conclusion PTEN gene may play a role in the inhibitory effect on the growth, grading and metastasis of OSCC. The expression of PTEN can be used as a reference marker for judging prognosis of patients with OSCC.