摘要
目的 :探讨基因编码蛋白 P73和 P53在胃癌中表达的相关性 ,以及与临床病理特征的关系。方法 :应用免疫组织化学方法 (S- P法 )检测 39例胃癌及 17例萎缩性胃炎、4 0例慢性炎性息肉中的 P73、P53蛋白的表达情况 ,并结合临床病理资料进行统计学分析。结果 :P73蛋白在胃癌中高表达 ,阳性率为 6 4 .1% ,与慢性炎性息肉组、萎缩性胃炎组比较有显著性差异 (P<0 .0 5 ) ;P73与组织学分型、TNM分期、淋巴结转移无相关 (P>0 .0 5 ) ;P53蛋白在胃癌中的阳性表达率为 6 4 .1% ,与慢性炎性息肉组、萎缩性胃炎组比较有显著性差异 (P<0 .0 5 ) ,与组织学分型、TNM分期、淋巴结转移无相关 (P>0 .0 5 )。结论 :P73高表达可能是一个胃癌发生的热点基因变化 ,基因蛋白 P73在胃癌中的表达对胃癌的发生发展可能起着重要作用 ,P73作为一个抑癌基因 ,有其组织特异性。P73和 P53蛋白虽然具有很高的同源性 ,但二者对胃癌的发生并无协同作用。
Objective:To study expression of P 73,P 53 protein in gastric carcinoma and their correlation and the relation of c linicopathological characteristic.Methods:Immunohistochemical method(S-P metho d)was used to detect the expression of P 73,P 53protein in 39 gastric carcinoma,17 chronic atrophic gastritis and 40 chronic inflammatory po lyp and statstical analysis was made combined with clinicopathogical data.Result s:The positive rate of P 73protein in gastric carcinoma was 64.1% and it was markedly higher than that in chronic inflammatory polyp and that in chronic atrophic gastritis(P<0.05).The positive rate of P 53pr otein in gastric carcinoma were 64.1%.Compared with chronic inflammatory polyp group and chronic atrophic gastritis group,the difference were significant(P <0.05).There were no correlation between P 73protein,P 53 protein.Conclusion:Probably high expression of P 73is one hot spot gene alteration of gastric carcinoma and expression of P 73 protein in gastric carcinoma may play an important role during the course of c ancerous development.As one tumor suppressor gene,P 73has its tiss ular specificity.Cooperative exprssion of though P 73and P 53 have high,they had no action of cooperative expression in gastric carci noma development.
出处
《临床医药实践》
2004年第12期892-895,共4页
Proceeding of Clinical Medicine
