微粒化纯化的黄酮成分治疗痔急性发作的多中心自身对照临床研究

A multicentral self controlled clinical study on the effect of Alvenor on acute attack of hemorrhoids

目的 前瞻性评估微粒化纯化的黄酮成分 (爱脉朗 )治疗痔疮急性发作的疗效和安全性。方法 采用自身前后对照研究方法。按照预先设定的入组标准从全国 2 9家医院收治 110 3例痔疮急性发作的患者。按照预先设定的评分标准 ,分别在患者就诊时 (0天 ) ,门诊随诊第 4天 ,第 7天对入选患者的痔疮疼痛、便血、肛门脱垂、肛门瘙痒、肛门水肿 ,肛周糜烂等临床症状和体征进行打分 ,同时由医生和患者分别对患者的总体疗效进行打分。对各次随访患者分数变化的情况进行统计 ,评价爱脉朗对痔疮急性发作症状的疗效。结果 肛门疼痛、便血、肛门脱垂、肛门水肿、肛门瘙痒等症状体征评分均明显改善。结论 微粒化纯化的黄酮成分能有效缓解痔疮急性发作的症状。

Objective To evaluate the efficacy of Alvenor on acute attack of hemorrhoids Methods We have enrolled 1?103 cases with acute attack of hemorrihoids from 29 hospitals in all over the country treated by Alvenor. Dosage was 1?500 mg twice daily for four days followed by 1?000 mg twice daily for 3 days Signs and symptoms of pain, bleeding, prolapse, edema, pruritus were scored at day 0, day 4 and day 7 Global treatment efficacy assessment was conducted by both the doctors and the patients themselves Statistical analysis was conducted Results Pain, bleeding, prolapse, edema, pruritus etc were significantly improved Conclusion Alvenor is effective in the treatment of patients with acute attack of hemorrhoids especially in relief of symptoms such as pain, bleeding, prolapse etc