健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察

Clinical Observation on Jianpi Liqi Recipe for Treatment of 25 Cases of Distal Metastasis of Liver Cancer

目的:观察健脾理气中药对肝癌肝动脉化疗栓塞(TACE)促转移的干预作用。方法:50例原发性肝癌随机分为 TACE组和 TACE+健脾理气方组,于 TACE 前后测定血清血管内皮细胞生长因子(VEGF)水平,观察生存率和远处转移率。结果:TACE 治疗前后及两组间 VEGF 差异无显著性(P>0.05),TACE 组1、2年生存率分别为76%、40%,TACE+健脾理气方组1、2年生存率分别为72%、64%,两组2年生存率差异有显著性(P<0.01)。两组1、2年远处转移率分别为28%、52%和8%、24%,2年远处转移率差异有显著性(P<0.05)。结论:健脾理气中药对 TACE 促肝癌转移有一定的阻断作用,但 TACE 后短期内并未明显抑制 VEGF 的表达。

Objective:To observe interfering action of Chinese drugs for strengthening spleen and regulating Qi on promoting metastasis of transcatheter arterial chemoemboization(TACE)of liver cancer.Methods:50 cases of primary cancer of liver were randomly divided into TACE group and TACE plus Jianpi Liqi Recipe group,and serum vascular endothelial growth factor(VEGF)level before and after TACE was determined and the survival rate and the distal metastasis rate were observed.Results:There was no significant differences before and after TACE,and between the two groups(P>0.05).The survival rates of 1 and 2 years were 76%and 40% in TACE group,and 72% and 64% in TACE plus Jianpi Liqi Recipe group,respectively.There was a significant difference between the two groups in the survival rate of 2 years(P<0.01).The distal metastasis rates of 1 and 2 years were 28%,52%,and 8%,24% in the two groups with a significant difference in the distal metastasis of 2 years between the two groups(P<0.05).Conclusion:The drug for strengthening spleen and regulating Qi has a certain blocking action on TACE promoting metastasis of liver cancer,but TACE does not obviously inhibit depression of VEGF within a sort term.