抗结核药物联合中药肺痨宁治疗复治肺结核34例临床研究

Clinical Study on Antituberculotics Combined with Chinese Drug Feilaoning for Treatment of 34 Cases of Pulmonary Tuberculosis of Return Treatment

目的:研究和评价肺痨宁辅助治疗复治肺结核的疗效。方法:将67例复治菌阳性肺结核患者随机分为治疗组34例,对照组33例,治疗方案均为3Pa(H)L2VZ(TH)E(Ak)/6Pa(H)L2V,治疗组同时加用肺痨宁3个月。结果:治疗后1个月、3个月、6个月时,治疗组和对照组痰菌阴转率分别为61.8%、94.1%、97.1%和30.3%、75.8%、78.8%;病灶吸收率分别为73.5%、94.1%、97.1%和36.4%、75.8%、81.8%,差异有显著性(P<0.05或P<0.01)。治疗后1个月时,治疗组白介素-12(IL-12)较对照组高,差异有显著性(P<0.05);治疗后3个月时,治疗组γ-干扰素(IFN-γ)较对照组高,差异有显著性(P<0.05或 P<0.01)。结论:肺痨宁辅助治疗复治肺结核可缩短疗程,开辟了中医中药治疗该病的新途径。

Objective:To study and assess therapeutic effect of Fei Laoning in accessory treatment of pulmonary tuberculosis of retu treatment.Methods:67 cases of return treatment with positive tuberculomyces were randomly divided into a treatment group of 3 cases and a control group of 33 cases.They were all treated by the program,3Pa(H)L2VZ(TH)E(Ak)/6Pa(H)L2V,wit Feilaoning added to the treatment group for 3 months.Results:One,three and six months after treatment,the returning negativ rates for the bacterium in phlegm were 61.8%,94.1%,97.1%and 30.3%.75.8%,78.8%;the absorption rates of foci wer 73.5%,94.1%, 97.1% and 36.4%,75.8%,81.8% in the treatment group and the control group,respectively,with significan differences between the two groups(P<0.05 or P<0.01).Interlukin-12(IL-12)level 1 month after treatment and γ-interfero (IFN-γ)and IL-12 levels 3 months after treatment in the treatment group were higher than those in the control group(P<0.0 or P<0.01).Conclusion:Feilaoning can shorten therapeutic course in accessory treatment of pulmonary tuberculosis of retur treatment.