妊高征血中过氧化脂质和超氧化物歧化酶活性变化及意义

Changes in blood level of lipoperoxide and crythrocyte superoxide dismutase activity in pregnancy-induced hypertension and their significance

本文测定了40例正常孕妇、42例妊高征患者在孕晚期及产后3～4天的全血过氧化脂质(LPO)水平和红细胞超氧化物歧化酶(SOD)活性.结果:与正常孕妇对照组比较,妊高征组全血LPO水平显著升高(P<0.01),红细胞SOD活性显著降低(P<0.01),随病情加重,全血LPO水平升高及红细胞SOD活性降低更显著.本文结果提示:妊高征的发生发展与机体助氧化/抗氧化之间的平衡紊乱有一定关系.测定妊高征患者全血LPO水平有助于正确判断病情变化并指导临床治疗.

The lipoperoxide(LPO) level in whole blood and erythrocyte superoxide dismutase(SOD) activity were meas-ured in 50 cases of normal pregnancy and 42 cascs of preg-nancy-indueed hypertension(PIH). The blood samples were respectiveiy colleeted during late pregnancy and on the days 3～4 postpartum The results showed that the blood level of LPO was significantly higher and the erythrocytc SOD activity significantly lower in patients with PIH than those of normal pregnant womcn(P<0. 01). The more severe the PIH was, the higher the blood level of LPO was and the lower the erythrocyte SOD ac-tivity. The results suggested that the imbalance of perox-ide/antioxide in patients with PIH may be assoeiated with the pathogenesis of PIH, and measuring the blood level of LPO may be useful in determining the severity of PIH and making a deeision.