摘要
目的研究生长抑素血药浓度与门静脉压力、血中Glu、NO和ET-1浓度变化关系。方法对14例门静脉高压症患者采用静脉微量泵经外周静脉持续24h分别输入施他宁(250 ng／h)和善宁(50 ng／h),经TIPS术后门静脉留置导管直接测压动态观察门静脉压力变化,同时检测血中Glt、NO和ET-1浓度。结果施他宁和善宁应用后血中生长抑素血药浓度上升,门静脉压力明显下降,施他宁组血中生长抑素浓度低于善宁组的血药浓度,门静脉压力下降显著高于善宁组,施他宁的血药浓度与门静脉压力下降呈现直线相关性;两种药物应用后均出现Glu浓度显著下降,而NO和ET-1浓度无明显变化。结论采用静脉微量泵持续应用施他宁和善宁稳定维持生长抑素浓度,具有持续降低门静脉压力的作用,善宁的血药浓度虽高,但施他宁的降压作用更为显著。
Objective To study the effects of serum somatostatin concentraton on portal pressure in patients with portal hypertensioa Methods The changes of portal pressure in 14 patients with portal hypertension had been evaluated for 24 hours by direct measurement of portal pressure through a catheter placed in portal vein when somatostatin(250 ng/h)or octreotide(50 ng/h)was infused intravenously by means of a micro-infusion pump. The serum concentration of somatostatin, Glu, NO and EF-1 were determined when portal pressure was measured. Results Serum concentration of somatostatin was increased and portal pressure was decreased significantly after intravenous infusion of somatostatin or octreotide. The serum concentration of somatostain in patients with the infusion of somatostain was higher than that in patients with octreotide. The decrease of portal pressure in patients with somatostain was more than that in patients with octreotide. There was a liner correlation between the concentration of somatostain and portal pressure in patients with the infusion of somatostain. The decrease of Glu concentration and no changes of NO,ET-1 occurred in patients with the infusion of somatostain and octreotide. Conclusion The high concentration of somatostain can be maintained by intravenous infusion of somatostatin or octreotide. Although the serum concentration of somatostain in patients with the infusion of somatostain was higher than that in patients with octreotide , the decrease of portal pressure in patients with somatostain was more than that in patients with octreotide.
出处
《江苏医药》
CAS
CSCD
北大核心
2005年第1期9-11,共3页
Jiangsu Medical Journal
